Intern, Gene Delivery Process Development

Company: Disability Solutions
Location: Seattle
Posted on: November 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .Position SummaryWe are seeking an enthusiastic, self-driven individual to work within the Gene Delivery Process Development team. Our team develops the end-to-end processes and technologies to deliver the critical raw materials used in the manufacturing of engineered T cells, including viral vectors and gene editing raw materials (e.g. sgRNA, pDNA, Cas enzyme, RNPs, etc.). This team member will support process development, production, and characterization of viral vectors and gene editing raw materials to advance our programs and platforms.Key Responsibilities

• Design and execute hands-on experiments to develop and optimize cell and gene therapy process unit operations (e.g., suspension bioreactors, transfection, electroporation lysis, harvest/clarification, chromatography, tangiential flow filtration, etc.)
• Perform ex-vivo cell culture, including thawing, passaging, expanding, and cryopreservation of mammalian cells
• Prepare ribonucleoprotein complexes in vitro using recombinant protein and nucleic acid solutions
• Support technology development for manufacture of gene delivery raw materials
• Design and analyze lab experiments using statistical (DOE) methods and software
• Maintain proper documentation of experiments using an electronic lab notebook
• Summarize and present scientific data; communicate progress to project teams
• Maintain a safe work environment in accordance with policies, procedures, and regulationsQualifications & Experience
  • Currently working toward B.S. in Biological or Chemical Engineering, Virology, Molecular or Cellular Biology, Biochemistry, or related discipline
  • 0-2 years of hands-on experience with biological laboratory procedures (ie. aseptic technique, mammalian cell culture, transfection, electroporation, filtration, ultrafiltration/diafiltration, chromatography, cryopreservation)
  • Understanding of cell biology, molecular biology, and biochemistry including protein and nucleic acid structure and function
  • Familiarity with analytical techniques (e.g., PCR, flow cytometry, ELISA, HPLC, etc.)
  • Ability to apply scientific principles and engineering fundamentals to solve problems
  • Understanding of statistical methods of experimental design and familiarity with DOE software (e.g. JMP, Minitab, R, etc.)
  • Independently motivated with ability to multi-task, problem-solve, and coordinate activities within a team
  • Desire and drive to learn the biological mechanism of cell and gene therapy products and passion for their impact on the lives of patients with serious diseases
  • Ability to communicate clearly and concisely through oral presentation and technical writing
  • All candidates must be authorized to work in the US at the time of hire. Please note that immigration or visa sponsorship is not available for this position. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Renton , Intern, Gene Delivery Process Development, Other , Seattle, Washington